• Necati Enver, Elad Azizli, Sevtap Akbulut, Emel Çadallı Tatar, Muhammed Kürşad Yelken, Kayhan Öztürk, Hakan Coşkun, Ahmet Hakan Birkent, Zahide Çiler Büyükatalay, Ozan Bağış Özgürsoy, and Haldun Oğuz.
• Department of Otolaryngology, Pendik Training and Research Hospital, Marmara University, İstanbul, Turkey
• Turk J Med Sci. 2021 Apr 30; 51 (2): 819-825.

Background/AimThis study aimed to assess the inflammatory adverse reactions of vocal fold injection laryngoplasty with hyaluronic acid.Materials And MethodsThis study was a retrospective chart review of patients who underwent vocal fold injection augmentation with HA injection from January 2005 to September 2016 in nine different institutions. Demographic data, indication for injection, injection techniques, types of injection material, settings of procedure, and complications were reviewed. The types of complication, onset time, and management of complications were also noted.ResultsIn all, 467 patients were identified. The majority of patients had been injected under general anesthesia (n = 382, 84.7%). For injection material, two different types of hyaluronic acid were used: hyaluronic acid alone or hyaluronic acid with dextranomer. Complications occurred in nine patients (1.9%). The majority of complications were inflammatory reactions (n = 7, 1.47%). Main symptoms were dysphonia and/or dyspnea with an onset of 0 h to 3 weeks after the hyaluronic acid injection. Three patients were hospitalized, one of which was also intubated and observed in the intensive care unit for 24 h. Systemic steroids and antibiotics were the main medical treatment in the majority of cases. There was no statistical difference in complication rates between patients who received hyaluronic acid and those who received hyaluronic acid with dextranomer (P = 0.220).ConclusionHyaluronic acid can be considered as a safe substance for the injection of vocal folds with a low risk of inflammatory reaction.This work is licensed under a Creative Commons Attribution 4.0 International License.

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