• World Neurosurg · Feb 2021

    Review

    Drug-Resistant Epilepsy and Obstructive Sleep Apnea: Exploring a Link Between the Two.

    • Harinder Jaseja, Manish Goyal, and Priyadarshini Mishra.
    • Vellore EEG Center, Gwalior, Madhya Pradesh, India.
    • World Neurosurg. 2021 Feb 1; 146: 210-214.

    AbstractDrug-resistant epilepsy accounts for approximately one third of all epilepsy cases; yet its exact etiopathogenesis still remains under intense exploration. Several factors have been advocated for predicting drug resistance in patients with epilepsy. Obstructive sleep apnea (OSA) is a commonly prevalent sleep disorder that exhibits a bidirectional and strong comorbidity with epilepsy. The exact pathophysiology of this comorbidity is not yet clearly explained. This study analyzes the relationship between drug-resistant epilepsy and OSA, and the findings indicate a strong role of rapid eye movement sleep (REMS) in the pathogenesis of this relationship. It also emerges from the study that REMS reduction is a prominent feature of OSA, and drug resistance in patients with epilepsy and treatment of OSA has been shown to restore REMS in several studies with concomitant improvement in seizure control.Copyright © 2020 Elsevier Inc. All rights reserved.

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