• Małgorzata Knaś, Mateusz Maciejczyk, Katarzyna Sawicka, Hady Razak Hady, Marek Niczyporuk, Jerzy R Ładny, Jan Matczuk, Danuta Waszkiel, Małgorzata Żendzian-Piotrowska, and Anna Zalewska.
• Institute of Health Care Higher Vocational School, Suwalki, Poland.
• J. Oral Pathol. Med. 2016 Jul 1; 45 (6): 455-64.

ObjectiveThere is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva.Materials And MethodsSalivary flow rate, total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), the total amount of uric acid (UA), polyphenols (pPh), catalase (CAT), superoxide dismutase 2 (SOD2), specific activity of peroxidase (Px), as well as malondialdehyde (MDA), and advanced glycation end products (AGE) concentrations were determined in the unstimulated (UWS) and stimulated (SWS) whole saliva of patients with morbid obesity before and after bariatric surgery.ResultsIn both UWS and SWS, the total amount of TOS, OSI, SOD2, and MDA was statistically higher in patients with morbid obesity as compared to the healthy controls, as well as significantly lower in the patients treated surgically as compared to the obese patients. The median values of the total amount of TAS, CAT, UA, pPh, and specific activity of Px were significantly reduced in UWS and SWS in patients with morbid obesity as compared to the control group and also statistically elevated in patients after bariatric surgery as compared to the patients with morbid obesity.ConclusionsIn morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obese patients before and after treatment.© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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