• Pol. Merkur. Lekarski · Apr 2012

    Review

    [Calcimimetic drugs in stage 3-5 chronic kidney disease].

    • Alicja E Grzegorzewska and Leszek Niepolski.
    • Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych. alicja_grzegorzewska@yahoo.com
    • Pol. Merkur. Lekarski. 2012 Apr 1; 32 (190): 260-2.

    AbstractThis review is focused on results of application of calcimimetic drug--cinacalcet in the treatment of secondary hyperparathyroidism in patients in 3-5 stage chronic kidney disease (CKD), excluding dialysis patients (stage 5D CKD). Oral administration of cinacalcet (15-180 mg/day) significantly reduced plasma parathormone (PTH) concentrations (> or = 30% as compared to the baseline values), but simultaneously side effects occurred, among them hypocalcemia and hyperphosphatemia. Hypocalcemia was a reason for cinacalcet withdrawal in 2-15% of patients. There is a lack of studies showing the influence of advantages and disadvantages of long-term administration of cinacalcet on outcome of 3-5 stage CKD patients.

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