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- V V Ptushkin, A D Kulagin, E A Lukina, I L Davydkin, T S Konstantinova, V S Shamrai, N V Minaeva, D A Kudlay, E V Gapchenko, O A Markova, and A Y Borozinets.
- Botkin City Clinical Hospital.
- Terapevt Arkh. 2020 Sep 1; 92 (7): 77-84.
AbstractCurrently, the main pathogenetic method for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) is the treatment with recombinant monoclonal antibodies that block the C5 component of the complement system. Eculizumab is the first biotechnological drug, which is a monoclonal antibody, with proven clinical efficacy and safety for the treatment of patients with PNH, which is used in world clinical practice. In Russia, in the framework of the state program Development of the pharmaceutical and medical industry for 20132020 was developed Elizaria (JSC GENERIUM) the first biosimilar of the original drug eculizumab.
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