• I V Maev, D N Andreev, V M Govorun, E N Ilina, Y A Kucheryavyy, T S Oganesian, E V Melnikova, O V Zayratyants, T V Parfenova, L V Dzhedzheia, N V Kirillova, E A Maevskaya, A K Fomenko, E G Lobanova, A V Zaborovskii, and K A Kriukov.
• Yevdokimov Moscow State University of Medicine and Dentistry.
• Terapevt Arkh. 2020 Sep 3; 92 (8): 24-28.

AimDetermine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in the European part of the Russian Federation.Materials And MethodsAs part of a clinical laboratory study, from 2015 to 2018, 27 gastrobiopsy samples obtained from H. pylori-infected patients were analyzed. H. pylori infection was verified using a rapid urease test or a 13C-urea breath test. The values of the minimum inhibitory concentration (MIC) of antibiotics were determined by the diffusion method using E-test strips (BioMerieux, France) according to the recommendations of the manufacturer. The sensitivity of the isolates was determined for 6 antibacterial drugs (amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifampicin).ResultsAccording to the data obtained, resistance to amoxicillin was 0%, clarithromycin 11.1%, metronidazole 59.3%, levofloxacin 3.7%, tetracycline 0%, and rifampicin 14.8%. Dual resistance to clarithromycin and metronidazole was recorded in two isolates (7.4%).ConclusionThus, the first results of the evaluation of H. pylori antibiotic resistance in the European part of the Russian Federation indicate a low resistance of the microorganism to clarithromycin and quite high to metronidazole.

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