• Eur J Anaesthesiol · Jan 1996

    Randomized Controlled Trial Clinical Trial

    Onset time of topical analgesia with EMLA 5%: no reduction with glyceryl trinitrate.

    • M R Nott, C J Clemson, and J L Peacock.
    • Royal West Sussex Hospital, Chichester, United Kingdom.
    • Eur J Anaesthesiol. 1996 Jan 1; 13 (1): 17-20.

    AbstractMany adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P = 0.01).

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