• Clin. Immunol. · May 2020

    Case Reports

    COVID-19 in a patient with long-term use of glucocorticoids: A study of a familial cluster.

    • Yuanyuan Han, Mao Jiang, Da Xia, Lichao He, Xin Lv, Xiaohua Liao, and Jie Meng.
    • Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
    • Clin. Immunol. 2020 May 1; 214: 108413.

    AbstractClusters of patients with novel coronavirus disease 2019 (COVID-19) have been successively reported globally. Studies show clear person-to-person transmission. The average incubation period is 2-14 days, and mostly 3-7 days. However, in some patients, this period may be longer. Here, we report a familial cluster of COVID-19 where a 47-year-old woman with long-term use of glucocorticoids did not develop any symptoms within the 14-day quarantine period but was confirmed with COVID-19 by tested positive of antibody on day 40 after she left Wuhan. Almost at the same time, her father and sister were diagnosed with COVID-19. The results suggest that the long-term use of glucocorticoids might cause atypical infections, a long incubation period, and extra transmission of COVID-19.Copyright © 2020 Elsevier Inc. All rights reserved.

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