• Therapie · May 2013

    [Intracranial hemorrhages: epidemiology and implication of antithrombotic therapy].

    • Jérôme Varvat, Magali Epinat, Christophe Nuti, Jean-Christophe Antoine, Patrick Mismetti, and Pierre Garnier.
    • Unité Neurovasculaire, CHU, Saint-Étienne, France. jvarvat@9online.fr
    • Therapie. 2013 May 1; 68 (3): 143-7.

    ObjectiveIntracranial hemorrhage (ICH) is an antithrombotic treatment complication. Our study's goal is to assess the proportion of ICH occurring while the patient is on antithrombotic treatment. The secondary goal is to assess the proportion of "avoidable" ICH (anticoagulant overdosage, debatables indications).MethodsWe conducted a descriptive epidemiological single-center study of ICH during 2 years. We analyzed the type of ICH, the type of antithrombotic treatment, the level of anticoagulation and the relevance of antithrombotic treatment indication.ResultsOf the 400 patients admitted for an ICH, 131 (33%) were treated by antithrombotic therapy: oral anti-vitamin K anticoagulants (VKA) in 14.1% of cases and antiplatelet agents in 15.1%. Of VKA patients, overdosage rate was 30.2%. The indication of antithrombotic therapy was debatable in 18.3% of cases.ConclusionOur study highlights the frequency of ICH occurring on antithrombotic therapy and the significant proportion of "avoidable" ICH.© 2013 Société Française de Pharmacologie et de Thérapeutique.

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