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Diagn. Microbiol. Infect. Dis. · Aug 2017
Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo-β-lactamase-producing gram-negative pathogens.
- Eric Wenzler, Matthew F Deraedt, Amanda T Harrington, and Larry H Danizger.
- College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: wenzler@uic.edu.
- Diagn. Microbiol. Infect. Dis. 2017 Aug 1; 88 (4): 352-354.
AbstractThis study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae. None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.Copyright © 2017 Elsevier Inc. All rights reserved.
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