• Cardiology in the young · Mar 2018

    Case Reports

    Rapid regression of large cardiac rhabdomyomas in neonates after sirolimus therapy.

    • M David Weiland, Kristin Bonello, and Kevin D Hill.
    • 1Department of Pediatrics,Division of Pediatric Cardiology,Duke University Hospital and Health Center,Durham,NC,United States of America.
    • Cardiol Young. 2018 Mar 1; 28 (3): 485-489.

    AbstractCardiac rhabdomyomas are the most common tumours in children and are typically seen in association with the tuberous sclerosis complex. Although benign and often associated with spontaneous regression, in rare circumstances surgical resection is indicated to relieve obstruction or other mass-related effects. Recent clinical trials have demonstrated the benefits of mammalian target of rapamycin inhibitors for the treatment of other tumour sub-types associated with tuberous sclerosis. Here we report rapid regression of several massive cardiac rhadomyomas in two neonates with the use of the mammalian target of rapamycin inhibitor sirolimus.

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