• Amy M Kwok, James W Davis, Rachel C Dirks, Mary M Wolfe, and Krista L Kaups.
• Department of Surgery, UCSF Fresno, 2823 Fresno St., 1(st) Floor Fresno, CA, 93721, USA. Electronic address: akwok@fresno.ucsf.edu.
• Am. J. Surg. 2016 Dec 1; 212 (6): 1231-1236.

BackgroundThe safety and timing of venous thromboembolism (VTE) prophylaxis in patients with blunt splenic injuries is not well known. We hypothesized that early initiation of VTE prophylaxis does not increase failure of nonoperative management or transfusion requirements in these patients.MethodsA retrospective review of trauma patients with blunt splenic injury was performed. Patients were compared based on initiation and timing of VTE prophylaxis (<24 hours, 24 to 48 hours, 48 to 72 hours, and >72 hours). Patients who received VTE prophylaxis were matched with those who did not. Primary outcomes included were operation or angioembolization.ResultsA total of 497 patients (256 received VTE prophylaxis and 241 did not) were included. There was no difference in the number of interventions based on presence of or time to VTE prophylaxis initiation.ConclusionsEarly initiation (<48 hours) of VTE prophylaxis is safe in patients with blunt splenic injuries treated nonoperatively, and may be safe as early as 24 hours.Copyright © 2016 Elsevier Inc. All rights reserved.

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