• Borja Quiroga, Marta Sanz Sainz, Begoña Santos Sánchez-Rey, Patricia Muñoz Ramos, Alberto Ortiz, and Pablo Ruano.
• Nephrology Department, Hospital Universitario de La Princesa, Madrid, Spain.
• Intern Med J. 2022 May 1; 52 (5): 834-840.

BackgroundAcute kidney injury (AKI) during hospitalisation is frequent and associated with adverse outcomes.AimsTo evaluate the association between renal function recovery after AKI and short-term post-discharge mortality.MethodsThis is a retrospective study of all AKI episodes codified in the electronic records of a single centre in 2013 and 2014. Epidemiological data and comorbidities at baseline and laboratory values at admission and discharge were collected. Persistent kidney dysfunction after AKI was defined as a last serum creatinine equal or above 1.2-fold over baseline level. Patients were followed for 30 days after discharge.ResultsOut of 1720 evaluated patients, 1541 (89%) were analysed. Of them, 869 (56%) recovered renal function. Independent predictors of renal function recovery after AKI were lower baseline estimated glomerular filtration rate (eGFR) (P < 0.001), higher admission eGFR (P < 0.001) and haemoglobin (P = 0.016), milder AKI (P = 0.037), absence of a history of heart failure (P < 0.001) and lower admission blood pressure (P < 0.001). After discharge, 46 (3%) patients died in the first 30 days. Persistent kidney dysfunction was associated (P = 0.01) with and independently predicted (odds ratio 2.6; 95% confidence interval 1.2-5.4; P = 0.01) short-term post-discharge mortality.ConclusionsPersistent kidney dysfunction after an AKI episode is an independent predictor of 30-day post-discharge mortality. This information might help select AKI patients who require closer follow up and monitoring after discharge.© 2020 Royal Australasian College of Physicians.

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