• Chengcheng Yuan, Chunyan Qu, and Weigang Ji.
• Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.
• Medicine (Baltimore). 2020 Dec 24; 99 (52): e23475.

BackgroundOsteoporosis is usually one of the less perceived complications of chronic illness among children. Previous studies have shown that vitamin D supplementation may be valuable to bone density, especially among children with a deficiency of vitamin D. Yet, the results often remain inconsistent. Therefore, the present study investigates the clinical therapeutic effects of vitamin D supplementation to enhance children with bone mineral density.MethodsWe will search the randomised controlled experiment literature of vitamin D supplementation for bone mineral density, focusing on children, in 3 distinct English databases (EMBASE, MEDLINE via PubMed, and Cochrane Library) and 2 specific Chinese databases (China National Knowledge Infrastructure (CNKI) and WanFang databases). Additionally, we intend to explore the Clinical Trials.gov, reference lists of identified publication and the grey literature. Accordingly, we will use 2 independent authors to screen the literature, extract data, and research quality assessment. We will carry out all statistical analyses using RevMan 5.3 software.ResultsWe will systematically evaluate the clinical therapeutic effects of vitamin D supplementation to enhance children with bone mineral density.ConclusionThe present study will summarise the currently published pieces of evidence of vitamin D supplementation for bone mineral density in children to further comprehend its promotion and application.Ethics And DisseminationThe present study is a systematic review and meta-analysis founded upon existing or published studies; therefore, ethical approval is not applicable.Osf Registration NumberOctober 24, 2020. osf.io/7vtey. (https://osf.io/7vtey/).Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

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