• Medicine · Dec 2020

    Efficacy of Chinese herbal injections combined with fluoropyrimidine and oxaliplatin-based chemotherapy for advanced colorectal cancer: A protocol for systematic review and meta-analysis of randomized controlled trials.

    • Wang Shuo S 0000-0003-0099-4562 Guang'an men Hospital, China Academy of Chinese Medical Sciences. , Xueqian Wang, Ying Zhang, Tong Zhou, Shuaihang Hu, Peiyu Tian, Zheng Li, Yuxiao Li, Yuerong Gui, Jun Dong, and Wei Hou.
    • Guang'an men Hospital, China Academy of Chinese Medical Sciences.
    • Medicine (Baltimore). 2020 Dec 24; 99 (52): e23550.

    BackgroundFluoropyrimidine combined with oxaliplatin-based chemotherapy have become the first-line treatment for advanced colorectal cancer (CRC). Chinese herbal injections (CHIs), as an important part of TCM, have been widely applied as adjunctive treatments to chemotherapy in patients with advanced CRC. However, the efficacy of this combination therapy has not been evaluated comprehensively.MethodsWe will conduct this systematic review and meta-analysis in accordance with the Preferred Reported Items for Systematic Review and Meta-analysis (PRISMA) guidelines. 7 databases will be searched for related randomized controlled trials (RCTs) from their inception to August 31, 2020: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), SinoMED and Wanfang Database. Two researchers will perform study selection, data extraction, and assessment of risk of bias independently. The primary outcomes are the disease control rate (DCR) and the objective response rate (ORR), the secondary outcomes are progression-free survival (PFS), survival rate, quality of life (QoL) and adverse effects. Cochrane Review Manager (RevMan 5.3) software will be used to analyze the outcomes.Results And ConclusionThis systematic review will evaluate the efficacy of CHIs and fluoropyrimidine and oxaliplatin-based chemotherapy for advanced CRC so as to provide valuable evidence to the application of CHIs in advanced CRC.Systematic Review RegistrationINPLASY registration number: INPLASY2020100050.Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

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