• Medicine · Dec 2020

    Observational Study

    Association of malnutrition with postoperative complication risk after curative surgery for oral cancer: Observational study.

    • Yao-Te Tsai, Chia-Hsuan Lai, Tzu-Hao Huang, Ching-Chuan Hsieh, Ethan I Huang, Yi-Chan Lee, Hsuan-Keng Yeh, Ming-Shao Tsai, Geng-He Chang, and Cheng-Ming Hsu.
    • Department of Otorhinolaryngology-Head and Neck Surgery.
    • Medicine (Baltimore). 2020 Dec 24; 99 (52): e23860.

    AbstractMalnutrition is common among patients who have oral cavity squamous cell carcinoma (OSCC), but its effect on the incidence of postoperative complications remains uncertain. Validated nutrition and complication assessment tools were used to evaluate the effects of nutrition on the likelihood of postoperative complications after curative surgery for OSCC.A retrospective study that spanned January 2014 to December 2018 enrolled 70 patients who received curative surgery for OSCC. Nutritional status before surgery was evaluated with the scored Patient-Generated Subjective Global Assessment (PG-SGA), and patients were classified as either well-nourished (rating A) or malnourished (ratings B and C). Complications 30 days after the operation were graded using Clavien-Dindo classification. The perioperative clinicopathological characteristics of the groups were compared, and risk factors for postoperative complications were identified through logistic regression.A total of 44 (62.8%) patients formed the malnourished group, and they tended to be older (P = .03), weigh less (P = .001), have lower Body Mass Index (P = .003), higher PG-SGA scores (P < .001), higher neutrophil-to-lymphocyte ratio (P = .034), more postoperative complications (P < .001), and longer hospital stays (P = .021). Major complications (Clavien-Dindo classification ≥ IIIa) were experienced by 18.5% (n = 13) of patients and were more common in the malnourished group (P = .007). Multivariate logistic regression demonstrated that PG-SGA score ≥4 was an independent risk factor for postoperative complications (hazard ratio = 4.929, P = .008).Malnutrition defined using the PG-SGA is an independent risk factor for postoperative complications of curative surgery in patients with OSCC. More prospective studies are warranted to confirm our findings.Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

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