• Fan Huang, Siyi Zhao, Mingwang Qiu, Yitong Li, Xiaoxuan Zhan, Cunshu Wu, Chushuo Shi, Weipeng Sun, Guizhen Chen, and Yunxiang Xu.
• Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation.
• Medicine (Baltimore). 2019 Apr 1; 98 (15): e15108e15108.

BackgroundA large number of randomized controlled trials (RCTs) have shown that acupuncture (ACU) has certain advantages over pharmacotherapies in the treatment of primary osteoporosis (POP). However, due to the diversity of ACU treatments, its relative effectiveness have not yet been studied and explained. Therefore, based on the network meta-analysis (NMA), this study will compare the differences in the efficacy of multiacupuncture in the treatment of POP, to provide a reference for clinical treatment.MethodsWe will search PubMed, MEDLINE, Embase, the Cochrane Library, China National Knowledge Infrastructure (CHKD-CNKI), WANFANG database (Chinese Medicine Premier), Chinese Biomedical Literature database (CBM), and VIP for relevant RCTs of ACU treatments for POP, from their inceptions to January 2019. STATA 15.0 and GEMTC software will be used to perform a NMA. The evidence will be evaluated by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach and the type 1 error rate will be assessed by trial sequential analysis (TSA).ResultsThe results of this review will be submitted to a recognized journal for publication.ConclusionThis proposed systematic review will evaluate the different advantages of various types of ACU in the treatment of POP.RegistrationPROSPERO (registration number CRD42019122724).

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