• Pharmacol. Res. · Jul 2020

    Review

    Candidate drugs against SARS-CoV-2 and COVID-19.

    • Dwight L McKee, Ariane Sternberg, Ulrike Stange, Stefan Laufer, and Cord Naujokat.
    • Integrative Cancer Consulting, Aptos, CA, USA.
    • Pharmacol. Res. 2020 Jul 1; 157: 104859.

    AbstractOutbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2). Blockade of ACE2, the host cell receptor for the S protein of SARS-CoV-2 and inhibition of TMPRSS2, which is required for S protein priming may prevent cell entry of SARS-CoV-2. Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic.Copyright © 2020 Elsevier Ltd. All rights reserved.

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