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Randomized Controlled Trial Clinical Trial
Evaluation of glycopyrrolate and atropine as adjuncts to reversal of non-depolarizing neuromuscular blocking agents in a "true-to-life" situation.
- D A Cozanitis, J W Dundee, J D Merrett, C J Jones, and R K Mirakhur.
- Br J Anaesth. 1980 Jan 1; 52 (1): 85-9.
AbstractGlycopyrrolate, a quaternary ammonium anticholinergic compound, and atropine were evaluated in combination with neostigmine for antagonism of non-depolarizing neuromuscular block. A total of 641 patients were investigated in a "true-to-life" situation. The patients receiving glycopyrrolate with neostigmine had smaller changes in heart rate than those who received atropine. This was particularly apparent in patients with cardiovascular disease.
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