• Takao Kato, Toshiya Koitabashi, Takashi Ouchi, and Ryohei Serita.
• Department of Anesthesiology, Ichikawa General Hospital, Tokyo Dental College, 5-11-13, Sugano, Ichikawa-city, Chiba 272-8513, Japan. tkatoh@tdc.ac.jp
• J Clin Monit Comput. 2012 Dec 1; 26 (6): 459-63.

AbstractThe aim of the present study was to determine the effect of low-dose remifentanil on the monitoring quality of the Bispectral index for mechanically ventilated patients. Twelve patients who underwent elective surgery and required mechanical ventilation post-operatively were enrolled in this study with written informed consent. Eligible patients were divided into two groups. Patients in the remifentanil group received low-dose remifentanil (0.05-0.125 μg/kg/min) and propofol (1-3 mg/kg/h). Patients in the control group received propofol (1-3 mg/kg/h). Levels of sedation were evaluated by both the Richmond Agitation Sedation Scale (RASS) and BIS monitor (A2000-XP, version 4.0, Aspect Medical Systems, Newton, USA). Monitoring quality was assessed by a correlation between RASS and BIS values. These values were assessed by single regression analysis and a P value of <0.05 was considered significant. There was a significant correlation between RASS and BIS values (P = 3 × 10(-12), R (2) = 0.67) in the remifentanil group, but not in the control group (P = 0.50, R (2) = 0.057). The administration of low-dose remifentanil makes BIS a more precise tool for sedated patients under mechanical ventilation in the ICU.

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