• Sarah Al-Mazidi and Laila Y Al-Ayadhi.
• Department of Physiology, Faculty of Medicine, Imam Mohammed bin Saud Islamic University, Riyadh, Saudi Arabia, s.almazeedi@gmail.com.
• Med Princ Pract. 2021 Jan 1; 30 (2): 160167160-167.

ObjectivesThe aim of this study was to correlate plasma levels of the synaptic proteins α-synuclein and γ-synuclein in autism spectrum disorder (ASD) children in order to elucidate their possible contribution to the pathogenesis of ASD and to study their association with the severity of the disorder.Subjects And MethodsPlasma levels of α-synuclein and γ-synuclein were measured in 38 male children diagnosed with ASD and 40 healthy age-matched male children by ELISA.ResultsOur results showed that plasma levels of α-synuclein (18.02 ± 5.3 pg/mL) were significantly higher in ASD children than in control children (14.39 ± 2 pg/mL), and plasma levels of γ-synuclein were decreased in the ASD group (23.74 ± 7.7 pg/mL) compared to the control group (32.40 ± 6.8 pg/mL) (p < 0.0001). Our data also indicate that plasma levels of both α-synuclein and γ-synuclein are significantly associated with the severity of ASD.ConclusionsOur study showed that alteration in α-synuclein and γ-synuclein might be associated with ASD pathogenesis and could be an indicator of the severity of the disorder.© 2020 The Author(s). Published by S. Karger AG, Basel.

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