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- Xuebin Ji, Liping Zhang, Jun Peng, and Ming Hou.
- Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Rd, Jinan, Shandong, 250012, People's Republic of China. jmm7751@163.com.
- J Hematol Oncol. 2014 Oct 2; 7: 72.
AbstractImmune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The induction of T cell tolerance is an important mechanism by which the pathogenesis and treatment of immune thrombocytopenia can be studied. Studies regarding the roles of the new inducible costimulator signal transduction pathway, the ubiquitin proteasome pathway, and the nuclear factor kappa B signal transduction pathway in the induction of T cell tolerance can help improve our understanding of immune theory and may provide a new theoretical basis for studying the pathogenesis and treatment of immune thrombocytopenia.
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