• Trends in immunology · Dec 2020

    Review

    Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.

    • Andrew G Harrison, Tao Lin, and Penghua Wang.
    • Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
    • Trends Immunol. 2020 Dec 1; 41 (12): 1100-1115.

    AbstractThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. However, important questions remain regarding its transmissibility and pathogenesis. In this review, we summarize current SARS-CoV-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism. We further present advances in animal models that are important for understanding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing. When necessary, comparisons are made from studies with SARS to provide further perspectives on coronavirus infectious disease 2019 (COVID-19), as well as draw inferences for future investigations.Copyright © 2020 Elsevier Ltd. All rights reserved.

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