• Rebecca Seguin, David M Buchner, Jingmin Liu, Matthew Allison, Todd Manini, Ching-Yun Wang, Joann E Manson, Catherine R Messina, Mahesh J Patel, Larry Moreland, Marcia L Stefanick, and Andrea Z Lacroix.
• Division of Nutritional Sciences (Seguin), Cornell University, Ithaca; Fred Hutchinson Cancer Research Center (Seguin, Liu, Wang, LaCroix), Seattle, Washington. Electronic address: rebeccaseguin@cornell.edu.
• Am J Prev Med. 2014 Feb 1; 46 (2): 122-35.

BackgroundAlthough epidemiologic studies have shown associations between sedentary behavior and mortality, few have focused on older women with adequate minority representation and few have controlled for both physical activity and functional status.PurposeThe objective of this study was to determine the relationship between sedentary time and total; cardiovascular disease (CVD); coronary heart disease (CHD); and cancer mortality in a prospective, multiethnic cohort of postmenopausal women.MethodsThe study population included 92,234 women aged 50-79 years at baseline (1993-1998) who participated in the Women's Health Initiative Observational Study through September 2010. Self-reported sedentary time was assessed by questionnaire and examined in 4 categories (≤4, >4-8, ≥8-11, >11 hours). Mortality risks were examined using Cox proportional hazard models adjusting for confounders. Models were also stratified by age, race/ethnicity, body mass index, physical activity, physical function, and chronic disease to examine possible effect modification. Analyses were conducted in 2012-2013.ResultsThe mean follow-up period was 12 years. Compared with women who reported the least sedentary time, women reporting the highest sedentary time had increased risk of all-cause mortality in the multivariate model (HR=1.12, 95% CI=1.05, 1.21). Results comparing the highest versus lowest categories for CVD, CHD, and cancer mortality were as follows: HR=1.13, 95% CI=0.99, 1.29; HR=1.27, 95% CI=1.04, 1.55; and HR=1.21, 95% CI=1.07, 1.37, respectively. For all mortality outcomes, there were significant linear tests for trend.ConclusionsThere was a linear relationship between greater amounts of sedentary time and mortality risk after controlling for multiple potential confounders.© 2013 American Journal of Preventive Medicine Published by American Journal of Preventive Medicine All rights reserved.

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