• World Neurosurg · Mar 2021

    Neutrophil-to-Albumin Ratio As a Biomarker of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

    • Xin Zhang, Yumeng Liu, Sheng Zhang, Congkai Wang, Changsheng Zou, and Aimin Li.
    • Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China.
    • World Neurosurg. 2021 Mar 1; 147: e453-e458.

    ObjectiveThis study set out to investigate the relationships between the neutrophil-to-albumin ratio (NAR) in the early stages of aneurysmal subarachnoid hemorrhage (aSAH) and the occurrence of delayed cerebral ischemia (DCI).MethodsA total of 439 patients with aSAH were included in this retrospective study. NAR assessment was conducted on admission. The relationship between NAR and DCI was analyzed.ResultsEighty-four patients (23.7%) experienced DCI. NAR levels were significantly higher in patients with DCI after aSAH than without DCI (median [interquartile range] 0.350 [0.274-0.406] vs. 0.240 [0.186-0.300]; P < 0.001). NAR levels were correlated with World Federation of Neurological Surgeons (WFNS) grade and modified Fisher (mFisher) grade (r = 0.505 and 0.394, respectively). NAR and mFisher grade were the independent predictors of DCI. Under receiver operating characteristic curve, NAR levels exhibited a significant discriminatory capability (area under the curve [95% confidence interval] 0.812 [0.740-0.823]; P < 0.001). The predictive power of NAR levels was similar to mFisher grade (P > 0.05).ConclusionsNAR, in positive correlation with the severity of hemorrhage, appears to be a novel predictive biomarker of DCI after aSAH.Copyright © 2020 Elsevier Inc. All rights reserved.

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