• Respiratory medicine · Jul 2020

    Review

    Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?

    • Fabio Perrotta, Maria Gabriella Matera, Mario Cazzola, and Andrea Bianco.
    • Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
    • Respir Med. 2020 Jul 1; 168: 105996.

    AbstractSARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor.Copyright © 2020. Published by Elsevier Ltd.

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