• Marat Slessarev, Ron Somogyi, David Preiss, Alex Vesely, Hiroshi Sasano, and Joseph A Fisher.
• University Health Network, Toronto General Hospital, University of Toronto, Canada.
• Crit. Care Med. 2006 Mar 1; 34 (3): 829-34.

ObjectiveFio2 values of a new oxygen mask that exploits efficiencies afforded by sequential gas delivery (SGD) were compared to those of a nonrebreathing mask (NRM) and a Venturi oxygen mask.DesignProspective, single-blinded, randomized study.SettingLaboratory study.SubjectsEight healthy male volunteers.InterventionsVolunteers breathed through each of the masks at various minute ventilations (VE). Oxygen flows were 2, 4, and 8 L/min to the SGD mask but only 8 L/min to the other masks.Measurements And Main ResultsNet FIO2 was calculated from end-tidal fractional concentrations of oxygen and CO2 with the alveolar gas equation. Only the SGD mask at an oxygen flow of 8 L/min consistently provided both FIO2>0.95 (at resting VE) and higher FIO2 than the other masks at all VE. The SGD mask delivered FIO2 comparable to other masks at only a fraction of the oxygen flow and was characterized by a consistent relation between FIO2 and oxygen flow for a given VE.ConclusionWe conclude that SGD can be exploited to provide FIO2>0.95 with oxygen flows as low as 8 L/min, as well as accurate and efficient dosing of oxygen even in the presence of hyperpnea.

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