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J. Neurol. Neurosurg. Psychiatr. · Oct 2013
ReviewPrimary progressive multiple sclerosis: progress and challenges.
- Claire M Rice, David Cottrell, Alastair Wilkins, and Neil J Scolding.
- University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK.
- J. Neurol. Neurosurg. Psychiatr.. 2013 Oct 1;84(10):1100-6.
AbstractPrimary progressive multiple sclerosis (MS) has long been recognised as presenting great difficulties to our management of what is increasingly a treatable neurological disease. Here we review some basic and clinical aspects of primary progressive MS, and describe how the disorder in fact offers powerful insights and opportunities for better understanding multiple sclerosis, and from a practical perspective an invaluable clinical substrate for studying and treating progressive disability in MS. Difficult hurdles remain, however, and these too are reviewed.
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