• Jakob Garbe, Stephan Eisenmann, Jan W Kantelhardt, Florian Duenninghaus, Patrick Michl, and Jonas Rosendahl.
• Department of Internal Medicine I, University Hospital Halle, Halle (Saale), Germany.
• United European Gastroenterol J. 2020 Sep 14: 2050640620959153.

BackgroundReliable and safe sedation is a prerequisite for endoscopic interventions. The current standard is rather safe, yet, an objective device to measure sedation depth is missing. To date, anaesthesia monitors based on processed electroencephalogram (EEG) have not been utilised in conscious sedation.ObjectiveTo investigate EEG parameters to differentiate consciousness in endoscopic propofol sedation.MethodsIn total, 171 patients aged 21-83 years (ASA I-III) undergoing gastrointestinal and bronchial endoscopy were enrolled. Standard monitoring and a frontotemporal 2-channel-EEG were recorded. The state of consciousness was identified by repeated requests to squeeze the investigator's hand.ResultsIn total, 1132 state of consciousness transitions were recorded in procedures ranging from 5 to 69 minutes. Thirty-four EEG parameters from the frequency domain, time-frequency domain and complexity measures were calculated. Area under the curve ranged from 0.51 to 0.82 with complexity and optimised frequency domain parameters yielding the best results.ConclusionPrediction of the state of consciousness with processed EEG parameters is feasible, and results for sedation in endoscopic procedures are similar to those reported from general anaesthesia. These results are insufficient for a clinical application, but prediction capability may be increased with optimisation and modelling.

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