• Wenyuan Li, Jing Guo, Qiaoling Wang, Jianyuan Tang, and Fengming You.
• Hospital of Chengdu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Dec 18; 99 (51): e23216e23216.

BackgroundColorectal cancer (CRC) is a public health problem and the world's leading cancer killer. It is a disease with high incidence and mortality. Although chemotherapy has achieved some success in the treatment of CRC, drug resistance and tumor metastasis caused by chemotherapy are still the main causes of death in patients with CRC. Notably, many side effects associated with chemotherapy, such as nausea, vomiting, and peripheral neurotoxicity, are major challenges in the treatment of patients with CRC. Chinese herbal medicine (CHM) has been widely used as an adjunctive therapy for CRC, but its efficacy and safety are still uncertain. The aim of this systematic review is to assess the efficacy and safety of CHM for the treatment of CRC.MethodsA comprehensive retrieval will be performed in the following electronic databases: PubMed, Cochrane Library, EMBASE, Web of Science, CNKI, SinoMed, VIP, and Wan Fang Data. The methodologic quality of randomized controlled trials will be assessed using the Cochrane risk assessment tool. Review Manager 5.3 software will be used for data synthesis and analysis. Funnel plot analysis and Egger test will be used to assess publication bias. The Grading of Recommendations Assessment, Development and Evaluation standard will be used to generate summary of finding table.ResultsThe results of this systematic review will be used to summarize and evaluate the evidence from randomized controlled clinical trials of CHM as adjuvant therapy for CRC.ConclusionThis review will provide a detailed summary of the evidence to assess the efficacy and safety of CHM for CRC.Osf RegistrationDOI 10.17605/OSF.IO/X2SKJ.Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

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