• Tao Fan, Xing-Ming Zhong, Xiang-Cai Wei, Zhu-Lin Miao, Si-Ying Luo, Heng Cheng, and Qing Xiao.
• Department of Obstetrics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518003.
• Medicine (Baltimore). 2020 Dec 18; 99 (51): e23558.

AbstractThe diagnosis and treatment of unexplained recurrent spontaneous abortion (URSA) is an important and hot topic in the field of obstetrics and gynecology. During our clinical investigation (observation), we have found that URSA patients usually experience recurrent vaginitis or vaginal dysbacteriosis during periods of non-pregnancy, pregnancy, and post-abortion. However, there is no research on vaginal dysbacteriosis's influence on URSA. Using women with normal induced abortion as a control group, and using 16S rRNA sequencing, which helps to screen differentially expressed flora, this study discusses the relevance between differential bacteria at the genus level and the incidence of URSA. Another aim of this study is to determine whether certain pathogenic genera can cause an imbalance in immune tolerance of the maternal and fetal interface through regulatory chemokines, which leads to recurrent spontaneous abortion. This article has explored URSA pathogenesis from the perspective of differentially expressed vaginal flora, which has great theoretical significance for the early diagnosis and treatment of URSA.Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

23 keywords...

hide…