• Medicine · Dec 2020

    A protocol for an interventional study on the impact of transcutaneous parasacral nerve stimulation in children with functional constipation.

    • Giovanna Maria Coelho, Nilton Carlos Machado, Mary de Assis Carvalho, Rebeca Mayara Padilha Rego, Stefani Rabelo Vieira, OrtolanErika Veruska PaivaEVPDepartment of Surgery and Orthopedics - Division of Pediatric Surgery, Botucatu Medical School, São Paulo State University (UNESP), São Paulo, Brazil., and Pedro Luiz Toledo de Arruda Lourenção.
    • Botucatu Medical School, São Paulo State University (UNESP).
    • Medicine (Baltimore). 2020 Dec 18; 99 (51): e23745e23745.

    IntroductionTranscutaneous parasacral nerve stimulation (TPNS) via electrodes placed over the sacrum can activate afferent neuronal networks noninvasively, leading to sacral reflexes that may improve colonic motility. Thus, TPNS can be considered a promising, noninvasive, and safe method for the treatment of constipation. However, there is no published study investigating its use in children with functional constipation. This is a single-center, prospective, longitudinal, and interventional study designed to assess the applicability and clinical outcomes of TPNS in functionally constipated children.Patient ConcernsParents or guardians of patients will be informed of the purpose of the study and will sign an informed consent form. The participants may leave the study at any time without any restrictions.DiagnosisTwenty-eight children (7-18 years old) who were diagnosed with intestinal constipation (Rome IV criteria) will be included.InterventionsThe patients will be submitted to daily sessions of TPNS for a period of 4 or 8 weeks and will be invited to participate in semistructured interviews at 3 or 4 moments: 1 week before the beginning of TPNS; immediately after the 4 and/or 8 weeks of TPNS; and 4 weeks after the end of the intervention period. In these appointments, the aspects related to bowel habits and quality of life will be assessed.OutcomesThis study will evaluate the increase in the number of bowel movements and stool consistency, the decrease in the number of episodes of retentive fecal incontinence, and the indirect improvement in the overall quality of life.Conclusionwe expect that this study protocol can show the efficacy of this promising method to assist the treatment of children with functional constipation.Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

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