• Hongan He, Xiao Wang, Yanyan Xiao, Jialin Zheng, Jinjuan Wang, and Baoqing Zhang.
• The First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Dec 18; 99 (51): e23747e23747.

BackgroundMycoplasma pneumoniae pneumonia (MPP) is a common respiratory disease in children. Its incidence rate is increasing year by year. The drug resistance rate of macrolide antibiotics and other conventional treatment methods is higher, and there are limitations in clinical application. Traditional Chinese patent medicine (TCPM) is a powerful weapon to treat this disease. At present, there is no comparison of the safety and effectiveness of multiple TCPMs in the treatment of MPP in children. Therefore, we take the method of network meta-analysis to systematically compare the efficacy of various TCPMs in the treatment of this disease.MethodsWe will conduct comprehensive searches of Cochrane Library, PubMed, Web of Science, Clinical Trials, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Chinese BioMedical Literature, Wanfang Database, and other electronic databases. The time frame is set from the establishment of the database to October 2020. All randomized controlled trials that meet the inclusion criteria will be included in this study. The 2 researchers will independently screen the literature according to the inclusion criteria, extract the data, and assess the bias risk of the included study. We will evaluate all the obtained data and evidence through Bayesian network meta-analysis, and use Stata 15.0 to process and analyze the data.ResultsThrough this study, we will evaluate the efficacy and safety of a variety of TCPMs for the treatment of MPP in children.ConclusionThe purpose of this study is to provide a strong reference for clinical application of TCPMs in the treatment of MPP in children, and to provide an important basis for clinicians to make correct judgments and put forward accurate treatment plans.Ethics And DisseminationThis review does not involve any human or animal experiments and therefore does not require ethical approval.Inplasy Registration NumberINPLASY 2020100108.Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

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