• Ana I Pérez-Castañeda, Gilberto F Vázquez-de Anda, Patricia Cerecero-Aguirre, Rodolfo Rivas-Ruíz, María G Delaye-Aguilar, and Juan O Talavera.
• Multidisciplinary Health Clinic, Universidad Autónoma del Estado de México, State of Mexico. Mexico.
• Gac Med Mex. 2020 Jan 1; 156 (5): 424-429.

BackgroundIncreased pulse pressure (IPP) is associated with an estimated glomerular filtration ≤ 60/mL/min/1.73 m2; thus, it can be useful as a diagnostic test to identify people with K/DOQI stage III-b chronic kidney disease (CKD).ObjectiveTo determine the usefulness of IPP as a diagnostic test for K/DOQI stage III-b CKD.MethodDiagnostic test study that included adult patients without comorbidities, registered in the Health Workers Cohort. The CKD-EPI formula was used to calculate glomerular filtration. Pulse pressure was determined by subtracting diastolic from systolic blood pressure. Sensitivity, specificity, positive predictive value, negative predictive value and prevalence were calculated using standard formulas. A ROC curve was generated to determine the area under the curve.ResultsA total of 6,215 patients were included. An IPP ≥ 50 mmHg was observed to have a sensitivity of 74 %, specificity of 70 %, positive predictive value of 1 %, negative predictive value of 100 % and a prevalence of 1 %. The inflection point in the ROC curve to identify K/DOQI III-b CKD was 0.71.ConclusionAn IPP ≥ 50 mmHg is useful as a diagnostic test to identify people with K/DOQI stage III-b CKD.Copyright: © 2019 Permanyer.

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