• Enrique Reyes-Muñoz, Salvador Espino Y Sosa, Claudia M Flores-Robles, Lidia Arce-Sánchez, Nayeli Martínez-Cruz, and Pedro Gutiérrez-Castrellón.
• Coordinación de Endocrinología Ginecológica y Perinatal, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes. Ciudad de México, México.
• Gac Med Mex. 2020 Jan 1; 156 (Supl 3): S43-S50.

IntroductionGestational diabetes mellitus (GDM) affects between 5 and 40% of pregnant women. Recently different interventions with nutritional supplements have been evaluated for prevention of GDM.AimTo perform a synthesis of the evidence on the efficacy of nutritional supplements (myo-inositol, probiotics, and vitamin D) in the prevention of GDM.MethodsA systematic search in PubMed and Cochrane library was performed, including systematic reviews of randomized clinical trials (RCTs), published in English or Spanish until May 2020, using the keywords: "prevention", "gestational diabetes", "hyperglycemia and pregnancy", "supplementation", "probiotics", "myo-inositol" and "vitamin D".Results10 systematic reviews that met the inclusion criteria were analyzed. Myo-inositol supplementation compared to placebo decreased the incidence of GDM (RR: 0.44 [0.27-0.87]; five RCTs), low quality of evidence. Although the supplementation with vitamin D or probiotics during pregnancy could reduce the incidence of GDM the evidence is limited.ConclusionsMyo-inositol supplementation is effective for prevention of GDM in high-risk women. Supplementation with vitamin D or probiotics probably decreases the incidence of GDM.Copyright: © 2020 Permanyer.

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