• Yasuyuki Fukami, Takuya Saito, Takaaki Osawa, Takashi Arikawa, Tatsuki Matsumura, Shintaro Kurahashi, Shunichiro Komatsu, Kenitiro Kaneko, and Tsuyoshi Sano.
• Division of Gastroenterological Surgery, Department of Surgery, Aichi Medical University, Nagakute, Japan, yasuyuki490225@yahoo.co.jp.
• Med Princ Pract. 2021 Jan 1; 30 (2): 131-137.

ObjectiveThere are no previous studies analyzing the prognostic predictive value of adding the tumor factor (i.e., Tumor Burden (TB) score) to the Controlling Nutritional Status (CONUT) score for patients with hepatocellular carcinoma (HCC). This study aimed to investigate the value of the CONUT plus TB (CONUT-TB) score as a prognostic predictor in patients with HCC undergoing liver resection.MethodsBetween 2015 and 2018, 96 consecutive patients with HCC underwent liver resection at our institution. Patients undergoing repeated liver resection and combined resection of a metastatic lesion were excluded. Patients were divided into 2 groups according to their CONUT-TB scores according to a cutoff value. Clinicopathologic prognostic factors for survival were analyzed using a database containing the medical records.ResultsThe optimal cutoff value of the CONUT-TB score determined by using a minimum p value approach was 13 points. Among the 81 patients included in the analytic cohort, 71 patients had low (<13) and 10 patients had high (>13) CONUT-TB scores. The overall 3-year survival rate of patients following liver resection for HCC in the high-CONUT-TB group was significantly worse than that of patients in the low-CONUT-TB group (62.5 vs. 89.3%, p = 0.003). Multivariate analysis indicated that a high CONUT-TB score was independently associated with overall survival after liver resection (p = 0.010).ConclusionThe CONUT-TB score is a valuable predictor of survival in patients with HCC after liver resection.© 2020 The Author(s) Published by S. Karger AG, Basel.

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