• Aykut Kürşat Fidan, Gülin Uçmak, Bedriye Büşra Demirel, Hülya Efetürk, İpek Öztürk, Semra Demirtaş Şenlik, Burcu Esen Akkaş, and İnci Ergürhan İlhan.
• Department of Nuclear Medicine, Hitit University Çorum Erol Olçok Education and Training Hospital, Çorum, Turkey
• Turk J Med Sci. 2021 Jun 28; 51 (3): 1115-1122.

Background/AimThe aim of this study was to investigate the contribution of fluorine-18 (F-18) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging in staging of pediatric osteosarcoma patients and also to evaluate the ability of metabolic parameters from the primary tumor to predict tumor necrosis rate (TNR).Material And MethodsF-18 FDG-PET/CT imaging was performed in staging 37 pediatric osteosarcoma patients. The metabolic pa- rameters SUVmax (maximum standardised uptake value), MTV (metabolic tumour volume), and TLG (total lesion glycolysis) were measured from the primary tumor. TNR level of the primary tumor was histopathologically measured after standard neoadjuvant chemotherapy treatment. The contribution of F-18 FDG-PET/CT to staging of pediatric osteosarcoma patients and the accuracy of metabolic parameters of the primary tumor to predict TNR were analized by regression analysis.ResultsMTV and TLG of the primary tumor were found to efficiently predict histopathologic TNR, whereas SUVmax was not (P = 0.012, P = 0.027, P = 0.25, respectively). Also 5 of 12 patients (41.6%) who were initially defined as localised osteosarcoma were upstaged in consequence of staging F-18 FDG-PET/CT findings.ConclusionF-18 FDG-PET/CT staging in pediatric osteosarcoma patients can effectively distinguish metastatic-localised disease. MTV and TLG values are important parameters, which can efficiently be used to predict TNR.This work is licensed under a Creative Commons Attribution 4.0 International License.

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