• Xiaoqiu Yuan, Lei Shi, and Yu Chen.
• Spine Center, Department of Orthopaedics, Changzheng Hospital, Second Military, Medical University, No. 415 Fengyang Rd, Shanghai, 20003, China.
• Eur Spine J. 2021 Apr 1; 30 (4): 801-808.

PurposeOssification of the spinal ligament (OSL) is a disease characterized by progressive ectopic ossification or calcification in the tissues of spinal ligament. The molecular pathogenesis of OSL has not been clearly elucidated. Recently, ncRNAs was found to functionally participate in OSL development. This review summarized current knowledge regarding the deregulation and function of ncRNAs in OSL METHODS: Relevant studies on deregulation and function of ncRNAs in OSL were retrieved from the PubMed databases. Then, studies were manually selected for inclusion based on predefined criteria.Result14 studies were reviewed, with 4 studies about high throughput sequencing and microarray of ncRNAs, 8 studies relevant to the function of ncRNAs and 2 studies regarding the ncRNAs as the biomarker of OSL.ConclusionncRNA play a vital role in the ossification of spinal ligament fibrocyte, including cell osteogenesis and inflammation. ncRNAs also have potential clinical utilities as therapeutic targets, risk predication and early detection in the management of OSL.Level Of Evidence IDiagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding.

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