• Jugdeep K Dhesi, Stephen H D Jackson, Lindsay M Bearne, Caje Moniz, Michael V Hurley, Cameron G Swift, and Theresa J Allain.
• Elderly Day Hospital, Thomas Guy House, Guys Hospital, St Thomas Street, London, UK. jugdeep.dhesi@gsst.nhs.uk
• Age Ageing. 2004 Nov 1; 33 (6): 589-95.

Backgroundvitamin D supplementation reduces the incidence of fractures in older adults. This may be partly mediated by effects of vitamin D on neuromuscular function.Objectiveto determine the effects of vitamin D supplementation on aspects of neuromuscular function known to be risk factors for falls and fractures.Designrandomised, double-blind, placebo-controlled study.Settingfalls clinic taking referrals from general practitioners and accident and emergency department.Subjects139 ambulatory subjects (>/=65 years) with a history of falls and 25-hydroxyvitamin D (25OHD) Interventionpatients were randomised to receive a single intramuscular injection of 600,000 i.u. ergocalciferol or placebo.Outcome Measuresassessments including biochemistry, postural sway, choice reaction time (CRT), aggregate functional performance time (AFPT), and quadriceps strength were carried out at baseline and 6 months post-intervention.Resultsbaseline characteristics were comparable between both groups. 25OHD in the treatment group increased significantly at 6 months. AFPT deteriorated in the control group and improved in the intervention group, representing a significant difference between groups (+6.6 s versus -2.0 s, t = 2.80, P < 0.05). Similar changes were observed for CRT (-0.06 s versus +0.41 s, t = -2.52, P < 0.01) and postural sway (+0.0025 versus -0.0138, t = 2.35, P < 0.02). There was no significant difference in muscle strength change between groups (-10 N versus -2 N, t = -1.26, ns). A significant correlation between change in AFPT and change in 25OHD levels was observed (r = 0.19, P = 0.03). There was no significant difference in the number of falls (0.39 versus 0.24, t = 1.08, P = 0.28) or fallers (14 versus 11, P = 0.52) between two groups.Conclusionsvitamin D supplementation, in fallers with vitamin D insufficiency, has a significant beneficial effect on functional performance, reaction time and balance, but not muscle strength. This suggests that vitamin D supplementation improves neuromuscular or neuroprotective function, which may in part explain the mechanism whereby vitamin D reduces falls and fractures.

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