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Case Reports
Hypokalaemia and peripheral oedema in a Cushingoid patient with metastatic prostate cancer.
- L M Schepers, J M H Kisters, C Wetzels, and G J Creemers.
- Department of Internal Medicine, Catharina Hospital, Eindhoven, the Netherlands.
- Neth J Med. 2020 Dec 1; 78 (6): 401-403.
AbstractWe report on a 75-year-old man with a history of metastatic prostate cancer who presented with haematuria, peripheral oedema, metabolic alkalosis, hypokalaemia, and hypertension. Laboratory evaluation was compatible with the diagnosis of adrenocorticotropic hormone (ACTH)-dependent cushing's syndrome and suggestive of ectopic ACTH production. Pathology of a prostate biopsy specimen showed a large cell neuroendocrine carcinoma (LCNEC) of the prostate. This report describes a case of Cushing's syndrome that was probably caused by ectopic ACTH secretion by a LCNEC of the prostate.
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