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Review
Biologic therapy for psoriasis--the first wave: infliximab, etanercept, efalizumab, and alefacept.
- Jeffrey M Weinberg, Ritu Saini, and William D Tutrone.
- Department of Dermatology, St. Luke's-Roosevelt Hospital Center, Beth Israel Medical Center, New York, New York, USA. jmw27@columbia.edu
- J Drugs Dermatol. 2002 Dec 1; 1 (3): 303-10.
AbstractOver the last several years, a new generation of therapies for psoriasis has been in development. These biologic therapies target the activity of T lymphocytes and cytokines responsible for the inflammatory nature of this disease. In this review, we present an update on the progress of the four biologic agents in the forefront: infliximab, etanercept, efalizumab, and alefacept. The mechanism of each drug will be reviewed, as well as the most recent efficacy and safety data.
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