• Internal medicine · Jun 2021

    Case Reports

    Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa.

    • Ryo Koda, Satoru Miyazaki, Noriaki Iino, Yo Sato, Kenichiro Hirano, Eiji Sunami, Shinichi Kosugi, Tsutomu Kanefuji, Akira Ogose, and Ichiei Narita.
    • Department of Nephrology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
    • Intern. Med. 2021 Jun 1; 60 (11): 1731-1736.

    AbstractA 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she had undergone subtotal colectomy for colon cancer. Her serum 25-hydroxy vitamin D concentration was below the detectable level. In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fat-soluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia.

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