• Internal medicine · Jun 2021

    Review Case Reports

    Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review.

    • Takeshi Matsumoto, Ryusuke Kusabiraki, Akiko Arisawa, Takahiro Fujiki, Akihiro Noda, Ayaka Tanaka, Naoki Yamamoto, Kensaku Aihara, Shinpachi Yamaoka, and Michiaki Mishima.
    • Department of Respiratory Medicine, Saiseikai-Noe Hospital, Japan.
    • Intern. Med. 2021 Jun 1; 60 (11): 1785-1788.

    AbstractEthambutol-induced optic neuropathy (EON) is a well-known complication, although low-dose ethambutol seldom causes EON. An 85-year-old man with non-tuberculous mycobacterial lung disease was taking antibiotics, including low-dose ethambutol. On day 85 of treatment, the diagnosis of EON was made. Despite prior discontinuation, his best corrected visual acuity drastically deteriorated from 20/17 (right eye) and 20/20 (left eye) to 20/330 (right eye) and 20/1,000 (left eye) within 3 weeks, and this symptom did not resolve. To our knowledge, there have been no reported cases with drastically progressing and irreversible EON even after the withdrawal of low-dose and short-term ethambutol.

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