• Revista médica de Chile · Sep 2020

    Survival rates of advanced estrogen-receptor positive breast cancer. Analysis of 211 cases.

    • César Sánchez, Francisco Domínguez, Héctor Galindo, Mauricio Camus, David Oddo, Alejandra Villarroel, Dravna Razmilic, José Peña, María Elena Navarro, Lidia Medina, Tomás Merino, Juan Briones, and Francisco Acevedo.
    • Departamento de Hematología-Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    • Rev Med Chil. 2020 Sep 1; 148 (9): 1233-1238.

    BackgroundAbout 80% of breast cancer (BC) cases express estrogen receptor (ER), which has been correlated with good prognosis and response to estrogen deprivation Aim: To characterize ER positive advanced BC (ABC) patients treated at our institution assessing the impact of clinical pre-sentation (stage IV, de novo disease at diagnosis versus systemic recurrence) and BC subtype on survival rates.Material And MethodsWe evaluated 211 ER+ advanced BC (ABC) patients, treated between 1997 and 2017.ResultsThe median overall survival (OS) was 37 months. Median OS for the period 1997/2006 and 2007/2017 were 33 and 42 months, respectively (p = 0.47). Luminal A, ABC stage IV disease at diagnosis displayed better OS rates than Luminal B stage IV tumors (100 and 32 months respectively, p < 0.01).ConclusionsClinical presentation (stage IV vs. systemic recurrence) and tumor subtype are key determinants of OS in ABC.

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