• Neurosurgery · Jun 1994

    Case Reports

    Successful adoptive immunotherapy with lymphokine-activated killer cells in the treatment of medulloblastoma disseminated via cerebrospinal fluid: case report.

    • A Silvani, A Salmaggi, G Parmiani, and A Boiardi.
    • Istituto Nazionale Neurologico C. Besta, Milan, Italy.
    • Neurosurgery. 1994 Jun 1; 34 (6): 1078-80; discussion 1080-1.

    AbstractWe report the case of a girl who developed cerebellar medulloblastoma at the age of 12 years and in whom, 4 years after surgical removal and radiotherapy, neoplastic dissemination via the cerebrospinal fluid took place. After only partially effective systemic and intrathecal chemotherapy, an intrathecal administration of lymphokine-activated killer cells and recombinant interleukin-2 allowed complete clinical recovery persisting after a follow-up of 30 months.

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