• Yueh-Hsin Lin, Vukshitha Dhanaraj, Alana E Mackenzie, Isabella M Young, Onur Tanglay, Robert G Briggs, Arpan R Chakraborty, Jorge Hormovas, R Dineth Fonseka, Sihyong J Kim, Jacky T Yeung, Charles Teo, and Michael E Sughrue.
• Centre for Minimally Invasive Neurosurgery Prince of Wales Private Hospital, Sydney, Australia.
• World Neurosurg. 2021 Apr 1; 148: e218-e226.

BackgroundThe parahippocampal gyrus is understood to have a role in high cognitive functions including memory encoding and retrieval and visuospatial processing. A detailed understanding of the exact location and nature of associated white tracts could significantly improve postoperative morbidity related to declining capacity. Through diffusion tensor imaging-based fiber tracking validated by gross anatomic dissection as ground truth, we have characterized these connections based on relationships to other well-known structures.MethodsDiffusion imaging from the Human Connectome Project for 10 healthy adult controls was used for tractography analysis. We evaluated the parahippocampal gyrus as a whole based on connectivity with other regions. All parahippocampal gyrus tracts were mapped in both hemispheres, and a lateralization index was calculated with resultant tract volumes.ResultsWe identified 2 connections of the parahippocampal gyrus: inferior longitudinal fasciculus and cingulum. Lateralization of the cingulum was detected (P < 0.05).ConclusionsThe parahippocampal gyrus is an important center for memory processing. Subtle differences in executive functioning following surgery for limbic tumors may be better understood in the context of the fiber-bundle anatomy highlighted by this study.Copyright © 2021 Elsevier Inc. All rights reserved.

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