• Romina Libster, Gonzalo Pérez Marc, Diego Wappner, Silvina Coviello, Alejandra Bianchi, Virginia Braem, Ignacio Esteban, Mauricio T Caballero, Cristian Wood, Mabel Berrueta, Aníbal Rondan, Gabriela Lescano, Pablo Cruz, Yvonne Ritou, Valeria Fernández Viña, Damián Álvarez Paggi, Sebastián Esperante, Adrián Ferreti, Gastón Ofman, Álvaro Ciganda, Rocío Rodriguez, Jorge Lantos, Ricardo Valentini, Nicolás Itcovici, Alejandra Hintze, M Laura Oyarvide, Candela Etchegaray, Alejandra Neira, Ivonne Name, Julieta Alfonso, Rocío López Castelo, Gisela Caruso, Sofía Rapelius, Fernando Alvez, Federico Etchenique, Federico Dimase, Darío Alvarez, Sofía S Aranda, Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, María Silveyra, Gabriel Leberzstein, Alejandra Debonis, Juan Molinos, Miguel González, Eduardo Perez, Nicolás Kreplak, Susana Pastor Argüello, Luz Gibbons, Fernando Althabe, Eduardo Bergel, Fernando P Polack, and Fundación INFANT–COVID-19 Group.
• From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) - all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program-United Nations Population Fund-United Nations Children's Fund-World Health Organization-World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe).
• N. Engl. J. Med. 2021 Feb 18; 384 (7): 610618610-618.

BackgroundTherapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.MethodsWe conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms. The primary end point was severe respiratory disease, defined as a respiratory rate of 30 breaths per minute or more, an oxygen saturation of less than 93% while the patient was breathing ambient air, or both. The trial was stopped early at 76% of its projected sample size because cases of Covid-19 in the trial region decreased considerably and steady enrollment of trial patients became virtually impossible.ResultsA total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P = 0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.ConclusionsEarly administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dirección de Sangre y Medicina Transfusional del Ministerio de Salud number, PAEPCC19, Plataforma de Registro Informatizado de Investigaciones en Salud number, 1421, and ClinicalTrials.gov number, NCT04479163.).Copyright © 2021 Massachusetts Medical Society.

24 keywords...

hide…