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- Paolo Procacci, Fabio Francini, Massimo Zoppi, and Marco Maresca.
- Pain Center, Clinica Medica Generale, University of Florence, Florence Italy Istituto di Fisiologia Umana, University of Florence, Florence Italy.
- Pain. 1975 Jun 1; 1 (2): 167-175.
AbstractIn a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 days. In all subjects the cutaneous pain threshold showed damped oscillations both in the limb ipsilateral to the block and in the contralateral one. The analysis of these oscillations showed: (a) that the sympathetic control of the cutaneous pain threshold may be exerted through a negative feedback loop (skin-afferent input-CNS-sympathetic output-skin); (b) that the afferent discharge of a limb controls the contralateral sympathetic output through central mechanisms.
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