• Qiang Li, Jiajiong Wang, Guomin Liu, Meng Xu, Yanguo Qin, Qin Han, He Liu, Xiaonan Wang, Zonghan Wang, Kerong Yang, Chaohua Gao, Jin-Cheng Wang, and Zhongheng Zhang.
• 1 Orthopaedic Medical Centre, The Second Hospital of Jilin University, Changchun, Jilin, China.
• J. Int. Med. Res. 2018 Oct 1; 46 (10): 4071-4081.

AbstractObjective To investigate the association between time from hospital admission to intensive care unit (ICU) admission (door to ICU time) and hospital mortality in patients with sepsis. Methods This retrospective observational study included routinely collected healthcare data from patients with sepsis. The primary endpoint was hospital mortality, defined as the survival status at hospital discharge. Door to ICU time was calculated and included in a multivariable model to investigate its association with mortality. Results Data from 13 115 patients were included for analyses, comprising 10 309 survivors and 2 806 non-survivors. Door to ICU time was significantly longer for non-survivors than survivors (median, 43.0 h [interquartile range, 12.4, 91.3] versus 26.7 h [7.0, 74.2]). In the multivariable regression model, door to ICU time remained significantly associated with mortality (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.006, 1.017) and there was a significant interaction between age and door to ICU time (OR 0.99, 95% CI 0.99, 1.00). Conclusion A shorter time from hospital door to ICU admission was shown to be independently associated with reduced hospital mortality in patients with severe sepsis and/or septic shock.

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