• I A Steenstra, J R Anema, P M Bongers, H C W de Vet, D L Knol, and W van Mechelen.
• Coronel Institute for Occupational and Environmental Health, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands.
• Occup Environ Med. 2006 Nov 1; 63 (11): 718-25.

BackgroundLow back pain is a common medical and social problem associated with disability and absence from work. Knowledge on effective return to work (RTW) interventions is scarce.ObjectiveTo determine the effectiveness of graded activity as part of a multistage RTW programme.DesignRandomised controlled trial.SettingOccupational healthcare.Subjects112 workers absent from work for more than eight weeks due to low back pain were randomised to either graded activity (n = 55) or usual care (n = 57).InterventionGraded activity, a physical exercise programme aimed at RTW based on operant-conditioning behavioural principles.Main Outcome MeasuresThe number of days off work until first RTW for more then 28 days, total number of days on sick leave during follow up, functional status, and severity of pain. Follow up was 26 weeks.ResultsGraded activity prolonged RTW. Median time until RTW was equal to the total number of days on sick leave and was 139 (IQR = 69) days in the graded activity group and 111 (IQR = 76) days in the usual care group (hazard ratio = 0.52, 95% CI 0.32 to 0.86). An interaction between a prior workplace intervention and graded activity, together with a delay in the start of the graded activity intervention, explained most of the delay in RTW (hazard ratio = 0.86, 95% CI 0.40 to 1.84 without prior intervention and 0.39, 95% CI 0.19 to 0.81 with prior intervention). Graded activity did not improve pain or functional status clinically significantly.ConclusionsGraded activity was not effective for any of the outcome measures. Different interventions combined can lead to a delay in RTW. Delay in referral to graded activity delays RTW. In implementing graded activity special attention should be paid to the structure and process of care.

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